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Total liver KD of C3 worsened liver injury, increased inflammasome activation, and triggered GSDMD-mediated pyroptosis

Mitochondrial aspartate deficiency disrupts the regeneration of the metabolic cofactor nicotinamide adenine dinucleotide (NAD), leading to ADP-denucleosylation of the endoplasmic reticulum (ER) sensor GRP78/BiP

Recommended Boosters: L-Carnitine for extra energy and NAC for liver detoxification

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Similarly, separate calibration curves were prepared for both Kynurenine and tryptophan for absolute quantification with Agilent Masshunter Quantitative Analysis for QQQ version 12.0, built on 12.0.893.1 software