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Biochem J 332 : 213221

By depleting populations of functional alveolar epithelial cells, ferroptosis prevents the repair of the alveolar-capillary barrier, leaving the lung vulnerable to further injury ( 5 Therapeutic targeting of ferroptosis in ARDS Given the central role of ferroptosis in ARDS pathogenesis, therapeutic strategies targeting ferroptotic pathways offer promising avenues to mitigate disease severity and improve outcomes