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The methodological quality of individual trials was also assessed according to a) whether randomization was concealed, b) blinding, c) analysis was based on the intention-to-treat (ITT) principle, d) patient selection, e) comparability of groups at baseline, f) extent of follow-up, g) description of treatment protocol and co-interventions, and h) definition of clinical outcomes

Severe gastrointestinal conditions: Those with delayed gastric emptying, gastroparesis, or chronic GI dysmotility may experience exacerbated symptoms due to the drugs action on gastric motility

The farnesoid X receptor (FXR) agonists demonstrate significant potential in alleviating intestinal inflammation and improving gut barrier function in IBD

Previous studies on DtxR showed that almost all mutations that destroy the DNA-binding properties are located on the metal binding site or helix H3

Therefore, EGCG can be esterified with long-chain saturated fatty acids and unsaturated fatty acids, and the structure can be modified to ultimately produce the lipated EGCG derivatives