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OM: Data curation, Formal Analysis, Funding acquisition, Resources, Software, Validation, Writingoriginal draft, Writingreview and editing

NayabDEFuDAliHKausarWAUroojSZafarMet alNano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective

This ensures effectiveness

As the target can be located in intracellular compartment of the brain parenchyma, the main determinant of successful application of the approach for delivery of drugs with the brain parenchymal intracellular targets is an improvement of unbound steady-state concentrations of released parent drug in intracellular compartment in comparison to parent drug dosing

the pi of one masking moiety may be in the range of 3 to 5, preferably 3.5 to 4.5, more preferably 3.9 to 4.5, while the pi of the other masking moiety is in the range of 5.0 to 7.0, preferably 5.5 to 6.0