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For example, p53 depletion can enhance cell proliferation and survival, disrupt apoptosis and increase genomic instability by altering the expression of REDD1, an mTOR suppressor

Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig

TT and RBG are supported by the Austrian Science Fund (FWF, SFB Lipid hydrolysis (F73), DK-MCD (W1226)

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297 However, overexpression of PINK1 inhibit the mtDNA-cGAS-STING pathway, so impaired mitophagy boosts inflammatory responses by promoting mtDNA DAMPs in aging