Preparation of RBC samples Human whole blood samples were obtained from Isfahan University of Medical Science following safety regulations and approved collection methods by the ethics committee
Building on this, we find that uridine supplementation significantly improves meiotic maturation, fertilization, and early embryonic development of aged oocytes, both in vivo and in vitro
2 Overview of the connection between gut microbiota and depression 2.1 Gut microbiota microenvironment The gastrointestinal tract is commonly referred to as the second brain due to its critical roles in digestion, immune response, and endocrine regulation ( The gut microenvironment primarily fosters the proliferation of bacterial phyla, such as Firmicutes , Bacteroidetes , Actinobacteria , Fusobacteria , Proteobacteria , Verrucomicrobia , and Cyanobacteria ( Firmicutes and Bacteroidetes dominate the fecal microbiota of healthy individuals, depressed individuals exhibit significant alterations, including decreased Lachnospiraceae and Ruminococcaceae , along with reduced populations of Fecalibacterium and Ruminococcus , and lower levels of Lactobacillus and Bifidobacterium ( 2.2 Evidence of gut microbiota in inducing depression Transferring the fecal microbiota from patients with major depressive disorder (MDD) into rodents has been shown to induce depression-like behaviors, suggesting the influence of gut microbiota on emotional states ( Figure 1 )
This manifests microscopically as hepatic necrosis, especially near the terminal hepatic vein, where cytochrome P450 enzymes are concentrated
Neurotherapeutics 14 , 7611 (2020)
