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One such mechanism involves the phosphorylation and activation of unc-51-like autophagy-activating kinase 1 (ULK1) by AMPK, which initiates a cascade that triggers autophagy

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The kynurenine pathway: A primary resistance mechanism in patients with glioblastoma

Alcohol Res: Curr Rev 38(2):163 Blanco AM, Valls SL, Pascual M, Guerri C (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes

That led us to wonder whether a compound with strong antioxidant capacity might protect HGF, either by preventing nitration or by compensating for the functional loss it causes. The team turned to two sulfur-based compounds known for strong antioxidant activity: glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS)