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In this randomized, double-blind, multicenter, parallel, placebo-controlled, phase 2b clinical trial, 52 weeks of abatacept treatment reduced RA development over two years compared to placebo

The peptide appears to regulate cell migration through its interaction with actin, a protein important for cell structure and movement

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Structural Formula Vector Image Title: Diethyl Maleate CAS Registry Number: 141-05-9 CAS Name: (2 Z )-2-Butenedioic acid, diethyl ester Additional Names: maleic acid, diethyl ester

Taylor and Francis, Washington, DC, p 176 Ito E, Takai A, Kondo F, Masui H, Imanishi S, Harada K (2002) Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds