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The main hormones involved are estrogen and progesterone, which are present in various forms of hormonal contraceptives such as birth control pills, patches, and rings

However, the altered tissue microenvironment characteristic of chronic metabolic and inflammatory diseases significantly impairs neutrophil function, resulting in aberrant responses and tissue damage

For patients with known comorbidities, medical clearance is needed before each session

TRP channels as cellular sensors

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)