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Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team

Identification of vitamin B12 as a modulator of LRRK2 activity constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors, Iban Ubarretxena, director of the Biofisika Institute and co-author of the study, said in a press release

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

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