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Obesity is believed to contribute to UF development primarily by elevating endogenous hormone levels, reducing serum hormone-binding globulin, altering estrogen metabolism during premenopausal conditions, and affecting the signaling controls of myometrial cells, such as insulin receptors, insulin-like growth factors, and peroxisome proliferator-activated receptors [31,32]

Additionally, no side effects were observed in the medakas in our study

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Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB

For further details regarding the methods used, please refer to the Supplementary Materials and Methods