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Age-related declines in mitochondrial function and increases in mitochondrial oxidant production are thought to be important contributors to the adverse effects of aging

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Due to the release of DNA and various enzymes that damage host tissues, NETs are highly pro-inflammatory

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Hypoxia-inducible factor-1 (HIF-1) and glycolysis In tumors, many cells are often exposed to hypoxic microenvironments where they cannot rely on OXPHOS and must modify their metabolism to survive in these conditions of reduced oxygen tension