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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

The Use of Low-Dose Naltrexone for Chronic Pain Kirbie M Bostick, Andrew G McCarter, Diane Nykamp PMID: 30821677 DOI: 10.4140/TCP.n.2019.43 Review:Med Sci (Basel) 2018 Sep 21;6(4):82