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Lu Y, Jiang Z, Wang K, et al

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5 Stepwise mediation analysis performed by R mediate package was conducted for multi-omic modules along the microbiome-metabolite-host axis to assess the relationship of the constitution related-microbiome with the tendency for anemia, with Hb, RBC, HCT, MCV, MCH, MCHC and RDW being a continuous dependent variable, and the tendency for anemia being a discrete dependent variable