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Research Applications and Benefits of CJC-1295 The available clinical studies report that CJC-1295 also induces a significant increase in insulin-like growth factor 1 (IGF-1), which is the main anabolic mediator of GH

Ipamorelin activates the same receptor family but with higher signaling selectivity

Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation

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