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Some studies suggest that this effect is achieved by inactivating GSK-3 and inhibiting the expression of PPAR (Sheng et al., 2013)

The majority of these are small-sample, single-center studies with short follow-up periods

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In the ovariectomized rat, single IV doses of zoledronic acid of 4-500 mcg/kg (0.1 to 3.5 times the human 5 mg intravenous dose, based on body surface area, mg/m2) suppressed bone turnover and protected against trabecular bone loss, cortical thinning and the reduction in vertebral and femoral bone strength in a dose-dependent manner

Several studies have shown that overexpression of CDC42 from neural stem cell-derived exosomes and Tp53-induced glycolysis and apoptosis regulator (TIGAR) significantly suppresses lipid peroxidation and ferroptosis, thereby promoting neurological recovery