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doi: 10.1016/j.freeradbiomed.2014.09.032 93 WangZ.FangJ

Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction: A review

Bock-Marquette and co-workers reported in Nature (2004) that Tb4 promotes cardiomyocyte survival post-myocardial-infarction in mice through PINCH/ILK/Akt signaling, and Smart and colleagues showed in 2007 that the same peptide mobilizes adult epicardial progenitor cells

Mater 4 (1), 99112

Survodutide is a concrete bet on that principle, and the reason it is studied so intensively is that the bet is testable: if the glucagon axis truly adds something, it should show up as extra weight loss, extra liver-fat reduction, and a distinct safety signature relative to GLP-1 alone