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However, as our immunofluorescence staining also showed a rapid (at 3.5 days) and dramatic (40%) decrease in the number of CC1-positive cells, another protein marker of mature OLs, an early onset of OL death is more likely

The discovery that the G2019S mutation results in a constitutive two- to threefold increase in LRRK2 kinase activity [141, 142], along with evidence that LRRK2 mutations are risk factors for the more common sporadic form of PD [143, 144], prompted extensive investigation into its functional role

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