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In preclinical work, BPC-157s neuro effects center on angiogenesis (via the VEGFR2AkteNOS pathway), nitric-oxide-system modulation, and neuroprotection, plus braingut neurotransmitter effects

Acknowledgements This work is financially supported by the National Key Research and Development Program of China (No

Toll-like receptors and nucleotide oligomerization domain (NOD)-like receptors are related to proinflammatory signals

p38 MAPK, a key protein that is abundantly expressed in multiple brain regions associated with cognitive function, can be activated by various inflammatory mediators, including cytokines, chemokines, and bacterial lipopolysaccharides (LPS)