Notably, these findings collectively highlight that NPC ferroptosis is a confirmed promotor of IDD by impairing the viability of NP-residing cells as well as damaging the extracellular matrix (ECM) 7,8 , while the operation-induced physical and biochemical insults could significantly promote the ferroptosis cascades in NPCs to enhance the degenerative phenotype as well as aggravate the IDD symptoms
Goldstein S, Samuni A, Merenyi G: Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations
7 , d793807 (2002)
Journal of Alzheimers Disease, 42(4), 10791149

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