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Patterson, M

NASH can lead to fibrosis, and scarring of the liver, and may progress to cirrhosis or liver cancer if left untreated

We have identified candidate HPX receptors and human proteins that bind to hemeHPX, i.e., HPX interactomes, in a human neutrophil model (promyelocytic HL-60 cells), in hepatoma HepG2 cells, and in primary human hepatocytes

FIGURE 3 Furthermore, a thorough mutagenesis study of Md ACO1, identified other important residues essential for ACO activity: C28, T157, K158, R175, Q188, K199, K230, R244, S246, K292, E294, E297, R299, F300, and E301 (Zhang et al., 2004