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As it related to this, one reason your B12 level is really high, is from inadequate B12 transportation and or inadequate cell membrane function

Ischemic preconditioning alleviates cerebral ischemia-reperfusion injury by interfering with glycocalyx

This disruption in vascular regulation could lead to inadequate perfusion of neural tissues, exacerbating neuronal vulnerability to ischemic insults and oxidative stress (Lambrechts et al