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For instance, H3K18la transcriptionally activates VCAM1, which subsequently activates the AKT-mTOR-CXCL1 axis, ultimately provoking EMT and migration of gastric cancer cells and resulting in immunosuppression and unfavorable prognosis

Another feature of AD is the accumulation of intracellular neurofibrillary tangles formed by phosphorylated Tau protein (50)

The circadian rhythm in murine cartilage decreases with age during OA development [140]

Don) Havil., Mitragyna hirsuta Havil., and Mitragyna rotundifolia (Roxb.) Kuntze

Ethics declarations Ethics approval and consent to participate All participants signed informed consent, and this study was performed with the approval of the Ethics Committee of the First Affiliated Hospital of Nanchang University