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The culture volume was 100 mL when not indicated

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These pharmacokinetic challenges prevent it from reaching an effective concentration in target tissues

doi:10.3389/fncel.2016.00243 pmid:27812322 Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, And S, Maggiolini M (2006a) 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30