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The knockdown of DNAJA1 also leads to the degradation of mutant-p53 by C-terminus of heat shock protein 70 (Hsc-70) interacting protein (CHIP), whereas its overexpression inhibits statin-induced mutant-p53 degradation

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These data have led us to focus our pre-clinical studies on interventions that reduce oxidative and inflammatory stress to improve vascular and nerve function

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