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Acetate, propionate, and butyrate are essential microbial metabolites that in addition to host-centric functions in energy metabolism and immunological control, affect bacterial communities by modifying luminal pH, suppressing pathogenic overgrowth, and regulating quorum-sensing pathways 43

Nguyen et al., 2018

The metabolite analysis demonstrated that Nrf2 strongly promotes purine nucleotide synthesis, resulting in the increased production of purine nucleotides

Formulations and compositions thus may be designed in accordance with the invention for delivery by any suitable route of administration

In conclusion, endothelial cells and cardiomyocytes show some commonalities in mitophagy, especially in maintaining mitochondrial function and responding to cellular stress