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The development of drugs targeting the CNS requires precise knowledge of their penetration into the brain 2 , and ideally, this information should be obtained as early as possible to avoid failure in late clinical development, when upward of $100 million is typically invested in a drug candidate

drug toxicity (e.g

Acute injuries may require twice-daily dosing initially, while chronic injuries may need prolonged once-daily treatment

More serious risks to be aware of include: Pancreatitis: As with other GLP-1 receptor agonists, there is a theoretical and observed risk of acute pancreatitis