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Is this a plaque psoriasis clinical trial in overweight adults only

Popovic M, Warr DG, Deangelis C, Tsao M, Chan KK, Poon M, Yip C, Pulenzas N, Lam H, Zhang L, Chow E

Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)

Additionally, TGF- is essential for regulating macrophage recruitment and function in fibrotic lesions, acting as a chemoattractant for these cells to fibrotic sites (101)