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It helps prevent a type of anemia called megaloblastic anemia, also known as vitamin B12 deficiency anemia, which results in symptoms like chronic fatigue and weakness

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In the U-shaped A 40 fibrils the 1 and 2 strands are staggered, and a for the U-shape geometry characteristic salt bridge D23-K28 connects chain (i) and (i+2) in L-fibrils, but chains (i) and (i-2) in DRI fibrils, see also Figure 8e in a later section of this paper

Published June 23, 2023