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Mol Immunol (2017) 91:13444

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Gpx4 fl/wt LysMCre + mice also displayed SLE-like clinical manifestations, including alopecia, lymphadenopathy, splenomegaly, proteinuria, significant increases in anti-dsDNA antibodies, IFN-, IL-6, and decreased complement C3 levels, indicating a close association between decreased neutrophil GPX4 protein expression and SLE pathogenesis