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Clinical trials, including the SURMOUNT-5 study, demonstrate tirzepatides ability to achieve 13.7-20.2% weight loss in individuals with obesity but without type 2 diabetes, outperforming other GLP-1 receptor agonists in direct comparisons

Among these diseases, the potential common denominators in the pathologic mechanisms are processes such as cell proliferation and differentiation, inflammation, and fibrosis, and the role of Wnt/-catenin signalling in these processes is well established, explaining why the Wnt/-catenin signalling pathway plays a key regulatory role in these diseases

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3.1 DNA oxidation products-8-hydroxy-2-deoxyguanosine Oxidative stress-induced DNA damage can be assessed using nucleoside derivatives, which act as indicators of oxidative damage

doi: 10.1007/s00011-010-0245-x 33 BrownDIGriendlingKK