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50 kg female 50kg body wt x 30mg (median of 20 & 40) = 1500mg/ day in 3 divided doses DURATION OF INTAKE FOR SKIN WHTENING Medium brown skin: 1-3 months Dark brown skin: 3-6 months Very brown skin: 6-12 months Black skin: 2 years Once a person has her desired skin color, the maintenance dose will just be 1 capsule of 500mg once daily

doi: 10.1038/s41582-022-00749-z, PMID: [DOI] [PubMed] [Google Scholar] Tziortzouda P., Van Den Bosch L., Hirth F

the invention provides for the modification (e.g., mutagenesis) of Fc domains

Cuproptosis is a copper iondependent form of programmed cell death that leads to abnormal oligomerization of lipoylated proteins and dysfunction of iron-sulfur cluster proteins in the mitochondrial tricarboxylic acid (TCA) cycle, thereby triggering intracellular oxidative stress and proteotoxic stress