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GPX4 expression was significantly downregulated in both mHSCs and LX-2 cells following miR-499a-5p mimic transfection (Fig

Oncol 11:273, 1992

Fasting increases AA uptake in the hypothalamus via SVCT2, leading to the downregulation of orexigenic neuropeptide expression The ARC of the hypothalamus serves as a central integrative center that regulates food intake through modulation of neuropeptide expression 41,42,43,44

In particular, microglia exposed to MIA exhibit blunted responsiveness to inflammatory stimuli, accompanied by epigenetic reprogramming including changes in chromatin accessibility and reduced transcription factor occupancy at open chromatin regions (Hayes et al., 2022)

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