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We then trialled an intravenous hydrocortisone infusion to simulate the cortisol circadian rhythm and demonstrated that in adrenal insufficiency, Addisons and CAH, we could improve disease control, providing proof of concept (PoC) for chronotherapy in adrenal insufficiency [11]

(PubMed) Olson GE, Winfrey VP, Hill KE, Burk RF

doi: 10.1038/s41573-021-00367-2 100 BerodLFriedrichCNandanAFreitagJHagemannSHarmrolfsKet al

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