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Wang J, Gao Y, Xiao L, Lin Y, Huang L, Chen J, et al

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Initial clinical failures, like that seen with VNP20009, have enlightened: a bacterial therapy for maximal efficacy should not be based on the removal of overall virulence, but on fine-tuned spatiotemporal control, provided by tools such as synthetic gene circuits (e.g., SLC and Cello)

toxicity remains rare when clinicians restrict injections to clinically indicated doses and monitor biochemical profiles

Laboratory tests have conrmed this enhancement of the antioxidant, detoxifying and protective abilities of vitamin C and Glutathione (the most powerful endogenous antioxidant)