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To achieve quantification and external validation, high-resolution imaging should be paired with mechanical measurements to resolve skin-surface microrelief trajectories and cellECM interaction forces, with standardized QC readouts across barrier function, secretome, and mechanics 131,134

This review encapsulates recent advancements in research, highlighting novel targets and agents, such as natural compounds, synthetic inhibitors, and clinical trial-stage candidates, all centered on ferroptosis strategies, to offer guidance for future therapeutic developments (Table 3)

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