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Turbulent flow promotes NF-B and AP-1 activity that upregulate pro-inflammatory and pro-atherogenic genes such as ICAM-1, E-selectin, platelet-derived growth factor (PDGF)-BB, IL-1a, bone morphogenic protein-4 (BMP-4), monocyte chemotactic protein-1 (MCP-1), and ET-1 [211]

In a gentamicin-induced acute kidney injury experiment in rats, expression of MuRF1 and MAFbx was increased in muscle and correlated with AKI severity, whereas the expression of the other three E3 ligases (Nedd4, Trim32, and Fbxo30 / MUSA1) was irrelevant

Kinetic studies on rat liver microsomal glutathione transferase, consequences of activation

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Results We observed that the animals with antibiotic-induced gut dysbiosis showed deficits in cognition, especially long-term memory consolidation