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This suggests that the inhibition of PI3K-SGK1 signaling contributes to the prolongation of action potential duration and QT interval ( Insulin receptor tyrosine kinase activates PI3K to produce phosphatidylinositol 3,4,5-trisphosphate, recruiting protein kinase B (Akt) and phosphatidylinositol 3-phosphate-dependent protein kinase 1 (PDK1) to the plasma membrane, leading to Akt activation

It is noteworthy that the identification of TMC1, originating from studies on genes associated with nonsyndromic sensorineural hearing loss [19], signifies a landmark achievement

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Metabotropic glutamate receptorsand neurodegenerative diseases

PMID: 9554461