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Vitamin B12, a crucial nutrient known for its role in maintaining nerve health and aiding in the production of DNA and red blood cells, has recently gained popularity in the field of aesthetic beauty

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The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

Since 2004, the government has included it in the medical insurance program in the USA

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