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Returning to the article, the authors claim there is sufficient evidence to say that any claim coming from observational studies is likely to be wrong

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Amycretin: Unimolecular dual GLP-1 and amylin receptor agonist

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This means cagrilintide and GLP-1 agonists are not competing for the same mechanism they are engaging the appetite-regulation system through separate but reinforcing pathways, which underpins the rationale for their combination