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Therefore, the challenges faced by BCV development and perspectives for accelerating clinical translation are introduced in the following aspects (Figure 2)

Such cases may represent patients who have not previously been able to maintain the long periods of restrictive diet or vigorous exercise regimens necessary to achieve the durable results typically afforded by existing therapeutic options, but who demonstrate tolerant behavior during short periods when administered under supervision

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Seniors should follow recommended dosages and watch for deficiency signs

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