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Kumar et al., 2009) characterized by polydipsia (increased thirst), polyuria (frequent urination), and polyphagia (increased hunger) with consequences of homeostasis disruption because of impaired glucose metabolism

Hepatocytes in particular demonstrate marked upregulation of the canonical Notch target gene, HES1 , compared to nonparenchymal cells, correlating with disease severity (132)

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Note that, while the level of IFN- in human serum is almost nil in the absence of infection, there is a low but detectable level of IFN- in bat serum (102, 103)

TB-500 is a synthetic version of Thymosin Beta-4 (TB4), a naturally occurring peptide found in virtually every cell in the human body