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doi:10.1007/978-3-031-02257-9_16

That way, if youre going to intervene with testosterone replacement or thyroid hormone or statins or whateverI mean, statins are mitochondrial toxins

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Although the biological mechanisms in terms of the effect on the brain and body are poorly understood, the molecular correlates of these effects operate through the major neurochemical system, amines (acetylcholine, dopamine, and serotonin) and the putative release of endogenous cannabinoids and endorphins, which may exert salutary effects on mood/anhedonia (Muzik and Diwadkar, 2019)

I wouldnt claim a direct lineage necessarily, but perhaps this boss bears some similarity to Ciarans original concept