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Abbreviations ABC: ATP-binding cassette ADCs: Antibody-drug conjugates ADCC: Antibody-dependent cellular cytotoxicity AML: Acute myeloid leukemia BBB: Blood-brain barrier CDx: Companion diagnostics CNS: Central nervous system DARs: Drug-to-antibody ratios DAMPs: Damage-associated molecular patterns DLBCL: Diffuse large B-cell lymphoma FDA: Food and Drug Administration FISH: Fluorescence in situ hybridization HPB: Hepatopancreatobiliary ICD: Immunogenic cell death IHC: Immunohistochemistry ILD: Interstitial lung disease LNPs: Lipid nanoparticles MDR: Multidrug resistance MMAF: Monomethyl auristatin F MMAE: Monomethyl auristatin E NSCLC: Non-small cell lung cancer OS: Overall survival ORR: Objective response rate PBD: Pyrrolobenzodiazepine PEG: Polyethylene glycol PFS: Progression-free survival PLD: Pegylated liposomal doxorubicin ROS: Reactive oxygen species RWE: Real-world evidence TAAs: Tumor-associated antigens TAMs: Tumor-associated macrophages TME: Tumor microenvironment TNBC: Triple-negative breast cancer TKI: Tyrosine kinase inhibitor References Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, et al

doi: 10.1007/s00125-019-05032-3 6 PipeleersDChintinneMDenysBMartensGKeymeulenBGorusF

In: Kay AB ed

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