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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2

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The orally active PK activator mitapivat is the first approved therapeutic agent that is clinically beneficial for effective treatment of patients with PK deficiency (15, 16)

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