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For instance, CHAC1 inhibitors could help mitigate oxidative stress in neurodegenerative diseases, while activators could enhance cancer cell death

The cooperation between private companies and researchers of different disciplines, as well as discussions on these approaches, are essential for the use of brain organoids as a proper model of mitochondrial diseases and neurodevelopmental disorders

Propionate, itself a substrate for intestinal gluconeogenesis, activates its expression via a gut-brain neural circuit involving the fatty acid receptor FFAR3 (245)

Among BD patients with elevated levels of the inflammatory marker IL-6, there were increases in Lactobacillales and Streptococcaceae , suggesting a connection between inflammation and gut microbiota changes