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A previous study demonstrated that deletion of ACSL4 and LPCAT3 prevents RSL3 and ML162-induced ferroptosis in KBM7 cells (51)

The elevated GSH level helps to prevent apoptosis of cancer cells by detoxifying reactive oxygen species (ROS) [3] and induce chemotherapeutic drugs resistance through GSH spontaneous reactions or xenobiotics reactions catalyzed by GSH S-transferase (GST) [4, 5]

doi: 10.1046/j.1440-1681.2002.03642.x 76 JonesWLiXZhi-ChaoQPerriottLWhitesellRRMayJM

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DXR significantly facilitated the effect of IF on tumor retardation (Scram-DXR +IF vs