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Keating, MKantarjian H, Gandhi V, OBrien S, Koller C, Kornblau S, Beran M, Andreeff M , Plunkett W, Freireich E

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Preclinical studies have demonstrated that NCoR1 depletion, followed by treatment with rapamycin, anti-mycin-A, or metformin restored TFEB activity and LC3 levels, leading to improved clearance of M.tb [28]

Notably, HK4 has only one kinase structure active site domain with enzymatic activity, whereas HK1, HK2, and HK3 possess two kinase structurally active site domains (n- and c-domains)

To examine this, we treated mice with titrated amounts of the AAV-TBG-Cre virus to induce varying degrees of Gclc deletion