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Chronic ketamine exposure in rodent models (50 mg/kg daily for 8 weeks) leads to significant activation of microglial cells and elevated expression of proinflammatory cytokines, such as IL-6 and IL-1, which correlate with hippocampal neuronal damage (Yin et al., 2022)

FIGURE 1 2.3 Biological and nutritional parameters At the end of the experiment, feed intake, weight gain, liver weight to body weight, and feed efficiency ratio were calculated following ( 2.4 Biochemical analysis of serum The following was used to calculate (LDL-C) and (VLDL-C): Bio-diagnostic Company, Egypt, for total serum cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) (Reitman and Frankel, 1957), while ALP was measured as outlined in Szasz, 1969)