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Furthermore, the increased expression of HO-1 in individuals suffering from heart failure serves to mitigate the adverse effects of pathological left ventricular remodeling, diminish myocardial hypertrophy, minimize oxidative stress, and abate inflammatory activation [96]

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The detoxification system converts lipid-soluble toxins to water-soluble molecules by conjugating (binding) the toxin to another molecule such as an amino acid, methyl group, or glutathione